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  • Silybum marianum - American Botanical Council

    Silbinin, a flavonoid from Silybum marianum (milk thistle), exhibited a concentration-dependent anticancer effect against non-small cell lung cancer lines via induction of G0/G1 cell cycle arrest and apoptosis, and the inhibition of tumor angiogenesis, migration, and invasion by downregulating phosphorylated EGFR expression, inhibiting the JAK2/STAT5 and PI3K/AKT …

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  • Silymarin as Supportive Treatment in Liver Diseases: A ...

    2020-2-17u2002·u2002Silymarin was first isolated in 1968 by German scientists at the University of Munich and then described and patented by the German herbal medicine manufacturer Madaus as a specific treatment 'against liver diseases' [].The first commercial preparation of silymarin was developed by Rottapharm/Madaus (Cologne, Germany) and complies with the analytical …

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  • Veterinary Herbal Medicine: A Systems-Based Approach

    2009-5-15u2002·u2002Immune-modulating herbs described earlier as immune stimulant are not always inappropriate but should be chosen with special attention to all of their purported effects. Focusing on maintaining systemic health rather than on suppressing the immune system is a worthwhile strategy, and herbal medicine is particularly useful when combined with the ...

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  • Molecules

    The application of natural plant extracts in UV-protection is popular and intensively studied. Silymarin (from Silibum marianum), a naturally occurring polyphenol, has recently received attention due to its antioxidant, anti-inflammatory and anti-apoptotic effects. However, its role in the UV-mediated keratinocyte cell response is still controversial.

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  • Systematic review of pharmacokinetics and potential ...

    Silymarin is an extract from the seeds (fruits) of Silybum marianum that contains flavonolignans and flavonoids. Although it is frequently used as a hepatoprotective agent, its application remains ...

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  • Role of nanocarriers and their surface modification in ...

    2020-1-1u2002·u2002Silybum marianum (L.) Gaertn, whose common name is milk thistle, is an edible plant belonging to the Asteraceae family, .Milk thistle is a native of the Mediterranean region and has also spread to East Asia, Europe, Australia, and the Americas. Since the first century, milk thistle has been used medicinally,,, .Its flowers, leaves, and roots have been used in the European …

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  • A Comprehensive Review of Natural Products against Liver ...

    2020-10-5u2002·u2002Silibinin is one kind of flavonolignans isolated from the plant Silybum marianum (L.) (milk thistle). It is the major bioactive component and accounts for approximately 60% of silymarin. In recent years, silibinin has been widely applied as a hepatoprotective compound for the treatment of a variety of liver diseases .

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  • Oilseed proteins – Properties and application as a food ...

    2020-12-1u2002·u2002Milk thistle (Silybum marianum L. Gaertner) is an annual plant indigenous to the Mediterranean area and Central Asia (India, Pakistan). Milk thistle pharmacological properties are connected with a high content of silymarin – a complex of seven flavonolignans and one flavonoid (taxifolin) that comprises up to 80% of milk thistle extract.

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  • Safety and toxicity of silymarin, the major constituent of ...

    Milk thistle (Silybum marianum) is a medicinal plant from the Asteraceae family. Silymarin is the major constituent of milk thistle extract and is a mixture of some flavonolignans such as silybin ...

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  • Chicory

    2020-6-18u2002·u2002Chicory can grow either in full sun or partial shade. This hardy herb does best in cool, temperate climates, but can survive in diverse conditions. Temperatures from 45 - 75°F (7 - 24°C) are acceptable, and seeds can be sown as early as …

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  • Role of nanocarriers and their surface modification in ...

    2020-1-1u2002·u2002Silybum marianum (L.) Gaertn, whose common name is milk thistle, is an edible plant belonging to the Asteraceae family, .Milk thistle is a native of the Mediterranean region and has also spread to East Asia, Europe, Australia, and the Americas. Since the first century, milk thistle has been used medicinally,,, .Its flowers, leaves, and roots have been used in the European diet as …

    Get Price
  • Silymarin: Friend or Foe of UV Exposed Keratinocytes ...

    2019-4-26u2002·u2002The application of natural plant extracts in UV-protection is popular and intensively studied. Silymarin (from Silibum marianum), a naturally occurring polyphenol, has recently received attention due to its antioxidant, anti-inflammatory and anti-apoptotic effects.However, its role in the UV-mediated keratinocyte cell response is still controversial.

    Get Price
  • Oilseed proteins – Properties and application as a food ...

    2020-12-1u2002·u2002Milk thistle (Silybum marianum L. Gaertner) is an annual plant indigenous to the Mediterranean area and Central Asia (India, Pakistan). Milk thistle pharmacological properties are connected with a high content of silymarin – a complex of seven flavonolignans and one flavonoid (taxifolin) that comprises up to 80% of milk thistle extract.

    Get Price
  • Journal of Agricultural and Food Chemistry

    Journal of Agricultural and Food Chemistry 2007, 55, 7, 2532-2535 (Article) Publication Date (Web): March 14, 2007. Abstract. Full text. PDF. ABSTRACT. Silibinin has recently received attention as a potential cancer chemopreventive agent because of its antiproliferative and anticarcinogenic effects.

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  • Large-scale separation of silybin diastereoisomers using ...

    The flavonolignan silybin (1), isolated from the seeds of milk thistle (Silybum marianum), occurs in nature as an equimolar mixture of two diastereoisomers, silybin A and silybin B, that exhibit different biological activities. The preparative production of optically pure silybin A and B in a diastereoisomeric purity greater than 95% was accomplished using immobilized Candida …

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  • Influence of phytogenics on recovery of the barrier ...

    Silymarin, the main active ingredient of Silybum marianum, was found to be effective in reducing the severity indicators of gastrointestinal mucositis in mice (Sasu et al., 2015). However, since mucositis is a disorder of the gastrointestinal tract resulting from chemotherapy, and no data on TEER or TJ were shown, a comparison to the present ...

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  • A Comprehensive Review of Natural Products against Liver ...

    2020-10-5u2002·u2002Silibinin is one kind of flavonolignans isolated from the plant Silybum marianum (L.) (milk thistle). It is the major bioactive component and accounts for approximately 60% of silymarin. In recent years, silibinin has been widely applied as a hepatoprotective compound for the treatment of a variety of liver diseases .

    Get Price
  • 142797-34-0

    SILYBIN (A and B)(P). CAS Number: 142797-34-0. Catalog Number: AA009HHZ. MDL Number: MFCD18827498. Molecular Formula: C25H20O10. Molecular Weight: 480.4203. AA Blocks.

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  • Transporter and its engineering for secondary metabolites ...

    2016-5-21u2002·u2002Secondary metabolites possess a lot of biological activities, and to achieve their functions, transmembrane transportation is crucial. Elucidation of their transport mechanisms in the cell is critical for discovering ways to improve the production. Here, we have summarized the recent progresses for representative secondary metabolite transporters and also the strategies for …

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  • Chicory

    2020-6-18u2002·u2002Chicory can grow either in full sun or partial shade. This hardy herb does best in cool, temperate climates, but can survive in diverse conditions. Temperatures from 45 - 75°F (7 - 24°C) are acceptable, and seeds can be sown as early as two …

    Get Price